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15.12. Ghrelin enhances food odor conditioning in healthy humans: An fMRI study

JE Han , J Frasnelli , Y Zeighami , K Larcher , J Boyle , T McConnell , S Malik , M Jones-Gotman , A Dagher

To read the full abstract: Cell Reports. 2018 Dec 4;25(10):26432652.e4.More on the gut and the reward response: Ghrelin has been reported to encourage eating through dopamine that is important for the reward response. Here, the authors injected 38 subjects with ghrelin, while exposing them to various odors, both food and non-food based. They were also shown r...

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ey0019.8-4 | Important for Clinical Practice | ESPEYB19

8.4. A multi-classifier system to identify and subtype congenital adrenal hyperplasia based on circulating steroid hormones

L Ye , Z Zhao , H Ren , W Wang , W Zhou , S Zheng , R Han , J Zhang , H Li , Z Wan , C Tang , S Sun , W Wang , G Ning

J Clin Endocrinol Metab. 2022; dgac271. PMID: 35512387 https://pubmed.ncbi.nlm.nih.gov/35512387/Brief Summary: This study, in a series of independent patient cohorts, developed and validated a clinical score, based on the circulating concentrations of 13 major steroid hormones, to detect and subtype Congenital Adrenal Hyperplasia (CAH).Steroidogenesis is a complex proc...

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ey0020.9-6 | Advances in Understanding Central Weight Regulation and Behaviour | ESPEYB20

9.6. Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior

Y He , B Brouwers , H Liu , K Lawler , EM de Oliveira , DK Lee , Y Yang , AR Cox , JM Keogh , E Henning , R Bounds , A Perdikari , V Ayinampudi , C Wang , M Yu , L Tu , N Zhang , N Yin , J Han , NA Scarcelli , Z Yan , KM Conde , C Potts , JC Bean , M Wang , SM Hartig , L Liao , J Xu , I Barroso , J Mokrosinski , Y Xu , IS Farooqi

Brief summary: This collaborative study identified 13 monoallelic rare loss-of-function (LoF) variants in the serotonin 2C receptor (HTR2C) gene in 19 unrelated individuals with hyperphagia, severe early-onset obesity, and some degree of maladaptive behaviour. The authors used exome sequencing in 2548 individuals with severe obesity and 1117 control individuals without obesity. They found that HTR2C variants cause monogenic obesity by demonstrating t...

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ESPE Yearbook of Paediatric Endocrinology

15.12. Ghrelin enhances food odor conditioning in healthy humans: An fMRI study

8.4. A multi-classifier system to identify and subtype congenital adrenal hyperplasia based on circulating steroid hormones

9.6. Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior

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